Predicting how influenza viruses change to evade immunity
Forecasting influenza evolution on a heterogeneous immune landscape
This study is looking at how flu viruses change to avoid the protection we get from past infections and vaccines, so we can better predict which strains will be common in the future and improve the flu vaccine for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10774269 on NIH RePORTER |
What this research studies
This research investigates how influenza viruses evolve to escape the immune responses generated by previous infections and vaccinations. By using a combination of experimental techniques and computational modeling, the team aims to accurately forecast which viral strains will dominate in upcoming flu seasons. They will map the genetic changes in the virus that affect its ability to evade immunity and create models to predict future viral evolution. The ultimate goal is to improve the selection of strains for the seasonal influenza vaccine, making it more effective for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals of all ages, particularly those who are at higher risk for influenza complications, such as young children and older adults.
Not a fit: Patients who are not affected by influenza or those who have contraindications to vaccination may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective influenza vaccines that better match circulating viral strains, reducing the incidence of flu and its complications.
How similar studies have performed: Previous research has shown promise in using computational models to predict viral evolution, indicating that this approach could yield significant advancements in vaccine development.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Bedford, Trevor Bc — Fred Hutchinson Cancer Center
- Study coordinator: Bedford, Trevor Bc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.