Predicting how chemicals affect living organisms using zebrafish
Discovering Chemical Activity Networks-Predicting Bioactivity Based on Structure
This study is looking at how different synthetic chemicals can be harmful by testing them on zebrafish embryos, which can help us learn more about how these chemicals might affect human health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon State University NIH-funded |
| Lab location | 1 site (Corvallis, United States) |
| Project ID | NIH-10873133 on NIH RePORTER |
What this research studies
This research investigates the toxicity of various synthetic chemicals by exposing millions of zebrafish embryos to them. The team will analyze changes in gene expression in the zebrafish to understand how these chemicals affect biological systems. By using CRISPR technology, they will modify the zebrafish genome to identify specific genes that are linked to the observed effects of the chemicals. This approach aims to provide insights that could be relevant to human health, as zebrafish share many genetic similarities with humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the effects of environmental chemicals on health, particularly those with conditions related to toxic exposures.
Not a fit: Patients who are not affected by environmental toxins or who do not have conditions related to chemical exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better predictions of chemical toxicity, improving safety assessments for human health.
How similar studies have performed: Previous research using zebrafish for toxicity screening has shown promising results, indicating that this approach is both effective and relevant.
Where this research is happening
Corvallis, United States
- Oregon State University — Corvallis, United States (Active)
Researchers
- Principal investigator: Tanguay, Robyn L — Oregon State University
- Study coordinator: Tanguay, Robyn L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.