Predicting high-risk sepsis patterns and finding targeted treatments for children with multiple organ dysfunction
Phenotype prediction and therapeutic targets in high-risk pediatric sepsis-associated MODS
This project uses hospital data to spot children with sepsis who are most likely to develop multiple organ failure and to find treatments that may help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11237188 on NIH RePORTER |
What this research studies
From a child's perspective, researchers will look at clinical information collected in pediatric intensive care units to find common patterns of sepsis that lead to worse outcomes. They will build tools that can recognize these high-risk patterns quickly so doctors can act sooner. The team will also search for biological targets and therapies that match each pattern, aiming to make treatments more precise for each child. The overall aim is to enable faster decisions and better matching of treatments for kids with sepsis and organ dysfunction.
Who could benefit from this research
Good fit: Children admitted to pediatric intensive care units with sepsis or early signs of multiple organ dysfunction (typically newborns through age 11) would be the main candidates.
Not a fit: Children without sepsis or organ dysfunction, adults, or patients whose condition is driven by unrelated chronic disorders may not benefit from this work.
Why it matters
Potential benefit: If successful, this could help doctors identify high-risk children earlier and match them to treatments that reduce organ failure and death.
How similar studies have performed: Previous data-driven work has identified risky sepsis patterns in children (like persistent low oxygen and shock), which gives promising leads, but directly matching treatments to those patterns is still largely untested.
Where this research is happening
Chicago, United States
- Lurie Children's Hospital of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Sanchez-Pinto, Lazaro Nelson — Lurie Children's Hospital of Chicago
- Study coordinator: Sanchez-Pinto, Lazaro Nelson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.