Predicting Heart Failure After a Heart Attack
Computational Stability Analysis to Predict Heart Failure after Myocardial Infarction
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11122278
This project uses computer models to understand why some people develop heart failure after a heart attack, helping us predict who might be at risk.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11122278 on ClinicalTrials.gov |
What this research studies
A heart attack can sometimes lead to heart failure, which significantly impacts many lives. After a heart attack, your heart undergoes changes in its size, shape, and how it works, a process called remodeling. While some of these changes can be helpful in the short term, others can unfortunately lead to worsening heart function and eventually heart failure. Currently, it's hard to predict which patients will experience these harmful changes. Our team is developing advanced computer models, informed by detailed heart imaging like MRI, to better understand these complex changes at a very detailed level.
Who could benefit from this research
Good fit: Patients who have experienced a myocardial infarction (heart attack) and are at risk for developing heart failure might be ideal candidates for future applications of this research.
Not a fit: Patients without a history of heart attack or those not at risk for heart failure would not directly benefit from this specific prediction tool.
Why it matters
Potential benefit: If successful, this work could lead to earlier identification of patients at high risk for heart failure after a heart attack, allowing for more timely and effective preventative treatments.
How similar studies have performed: Computational models of heart biomechanics, informed by imaging, show high potential, but this specific approach combining cell-scale and organ-scale modeling with stability theory is novel.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PFALLER, MARTIN R — YALE UNIVERSITY
- Study coordinator: PFALLER, MARTIN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases, Cardiac Disorders