Predicting harmful reactions to drugs based on protein interactions
Official title: Predicting adverse drug reactions via networks of drug binding pocket similarity
Funded at Stanford University · NIH-10951510 · Data updated 2026-11-12
This study is looking at how some medications might accidentally connect with the wrong proteins in our bodies, which can cause unwanted side effects, and it aims to find better ways to predict these issues so that medicines can be safer for everyone.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 30, 2023 |
| Project end | September 29, 2025 |
| Funding year | 2024 |
| Award (this year) | $42,507 |
| NIH project number | 5F31GM151783-02 |
| Project ID | NIH-10951510 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are prescribed medications and may be at risk for adverse drug reactions.
✕Less likely to help
Patients who are not currently taking medications or those with conditions that do not involve drug treatments may not benefit from this research.
What this research studies
This research investigates how drugs can unintentionally bind to proteins in the body, leading to adverse drug reactions (ADRs). By utilizing advanced 3D molecular structure predictions and structural informatics algorithms, the study aims to create methods that can predict these off-target interactions at a large scale. The approach involves building a graph of drug-binding pairs and estimating the potential ADRs associated with these interactions, ultimately guiding safer drug design. Patients may benefit from improved drug safety and reduced hospital visits due to ADRs.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of adverse drug reactions, leading to safer medication use for patients.
How similar studies have gone: Other research has shown promise in predicting drug interactions using molecular structures, indicating that this approach has potential for success.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Carpenter, Kristy — Stanford University
- Study coordinator: Carpenter, Kristy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.