Predicting eye inflammation in children with juvenile arthritis
Predicting uveitis onset in children with juvenile idiopathic arthritis
This study is looking to help kids with juvenile idiopathic arthritis by finding better ways to spot and treat uveitis, an eye condition they might get, by checking their tears and genes to see who might be at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10661602 on NIH RePORTER |
What this research studies
This research aims to improve the detection and treatment of uveitis, a serious eye condition that can affect children with juvenile idiopathic arthritis (JIA). By analyzing biomarkers in tears and identifying genetic risk factors, the study seeks to develop a tool that can predict which children are at higher risk for developing uveitis. The research involves enrolling 250 children recently diagnosed with JIA and monitoring them over time to gather data on their eye health and genetic information. This collaborative effort includes experts from various fields to ensure a comprehensive approach to prevention and management.
Who could benefit from this research
Good fit: Ideal candidates for this research are children recently diagnosed with juvenile idiopathic arthritis who do not currently show signs of uveitis.
Not a fit: Patients who have already developed uveitis or those without juvenile idiopathic arthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of uveitis in children, potentially preventing vision loss.
How similar studies have performed: Previous research has shown promise in using biomarkers and genetic factors to predict disease onset in similar conditions, indicating a potential for success in this approach.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Angeles-Han, Sheila Therese — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Angeles-Han, Sheila Therese
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.