Predicting eye inflammation in children with juvenile arthritis
Official title: Predicting uveitis onset in children with juvenile idiopathic arthritis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10661602 · Data updated 2026-11-12
This study is looking to help kids with juvenile idiopathic arthritis by finding better ways to spot and treat uveitis, an eye condition they might get, by checking their tears and genes to see who might be at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 30, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $625,855 |
| NIH project number | 5R01EY030521-05 |
| Project ID | NIH-10661602 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children recently diagnosed with juvenile idiopathic arthritis who do not currently show signs of uveitis.
✕Less likely to help
Patients who have already developed uveitis or those without juvenile idiopathic arthritis may not benefit from this research.
What this research studies
This research aims to improve the detection and treatment of uveitis, a serious eye condition that can affect children with juvenile idiopathic arthritis (JIA). By analyzing biomarkers in tears and identifying genetic risk factors, the study seeks to develop a tool that can predict which children are at higher risk for developing uveitis. The research involves enrolling 250 children recently diagnosed with JIA and monitoring them over time to gather data on their eye health and genetic information. This collaborative effort includes experts from various fields to ensure a comprehensive approach to prevention and management.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of uveitis in children, potentially preventing vision loss.
How similar studies have gone: Previous research has shown promise in using biomarkers and genetic factors to predict disease onset in similar conditions, indicating a potential for success in this approach.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Angeles-Han, Sheila Therese — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Angeles-Han, Sheila Therese
Related research
Other NIH-funded projects on the same topics.
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Stopping adalimumab treatment for children with arthritis-related eye inflammation
This study is looking at what happens when kids with juvenile idiopathic arthritis stop taking adalimumab, a medicine for eye inflammation, to see if they can safely go off it without their symptoms coming back.
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Deciphering What Drives Juvenile Idiopathic Arthritis in African American Children
This project looks at why African American children with juvenile idiopathic arthritis have more joint damage, using clinical data and genetic information to find factors that may explain the differences.
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Understanding how T cells make IFN-γ and IL-17 in kids with juvenile arthritis
A doctor-scientist at Vanderbilt is studying why certain immune cells in children with juvenile idiopathic arthritis produce inflammatory signals, with the goal of improving diagnosis and treatment.
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Lung disease linked to systemic juvenile idiopathic arthritis in children
This project looks at how ongoing immune activation and some arthritis medicines may cause lung inflammation and breathing problems in children with systemic juvenile idiopathic arthritis (SJIA).
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Linking JIA Registry with Claims Data to Improve Understanding of Juvenile Arthritis
A study will connect the CARRA JIA patient registry with a large national claims database to see how well registry data match real-world care and outcomes for children with juvenile idiopathic arthritis.
-
Investigating the role of viruses and gut bacteria in arthritis flares in children
This study is looking at how certain viruses and bacteria in the gut might affect flare-ups of juvenile idiopathic arthritis in kids, hoping to find clues that could help manage these painful episodes better.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.