Predicting dementia progression in Parkinson's disease using genetic information
Genome-Wide Prediction of Dementia in Parkinson's Disease
This study is looking at how your genes might help us understand if and when dementia could develop in people with Parkinson's disease, so we can find better ways to support those at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11075384 on NIH RePORTER |
What this research studies
This research investigates how genetic factors can predict the progression of dementia in patients with Parkinson's disease. By analyzing genetic data from over six thousand patients and their cognitive assessments, the study aims to identify specific genetic markers that indicate the risk of developing dementia. The approach involves a longitudinal analysis, which means it looks at changes over time rather than just a snapshot, providing a deeper understanding of how dementia develops in these patients. This could lead to better-targeted interventions and support for those at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who are at risk of developing dementia.
Not a fit: Patients with Parkinson's disease who do not exhibit any cognitive impairment or those who are not at risk for dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved predictions of dementia progression in Parkinson's patients, allowing for earlier interventions and better management of their care.
How similar studies have performed: Previous genome-wide association studies have shown some success in identifying genetic factors related to dementia, but this research aims to take a novel longitudinal approach that has not been extensively tested.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Scherzer, Clemens R — Yale University
- Study coordinator: Scherzer, Clemens R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.