Predicting breast cancer risk in women with benign breast conditions
Official title: Clinical breast cancer risk prediction models for women with a high-risk benign breast diagnosis
Funded at University of Vermont & St Agric College · NIH-10931667 · Data updated 2026-11-12
This study is looking at ways to help women with certain non-cancerous breast conditions understand their risk of developing breast cancer, so they can avoid unnecessary surgery if it's safe for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $686,647 |
| NIH project number | 5R01CA282725-02 |
| Project ID | NIH-10931667 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have been diagnosed with high-risk benign breast lesions following a core needle biopsy.
✕Less likely to help
Patients with benign breast conditions that do not fall into the high-risk category may not benefit from this research.
What this research studies
This research focuses on developing clinical models to predict breast cancer risk in women diagnosed with high-risk benign breast conditions. It aims to identify which patients can safely avoid surgical excision, a common procedure currently performed to rule out cancer. By analyzing various patient, pathologic, and radiologic factors, the study seeks to provide evidence-based guidelines for managing these high-risk lesions. Ultimately, the goal is to enhance prevention and detection strategies for women who may not need aggressive treatment.
Why it matters
Potential benefit: If successful, this research could help reduce unnecessary surgeries and improve personalized care for women with benign breast conditions.
How similar studies have gone: Previous studies have shown promise in identifying risk factors for breast cancer in similar populations, but this research aims to provide more definitive evidence.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Sprague, Brian L — University of Vermont & St Agric College
- Study coordinator: Sprague, Brian L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.