Predicting breast cancer risk in African American women using genetic information
Polygenic Risk Prediction of Breast Cancer for Women of African Descent
This study is looking at the genetic factors that affect breast cancer risk in African American women to create more accurate risk scores, helping to improve early detection and prevention for this group.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10892897 on NIH RePORTER |
What this research studies
This research focuses on understanding breast cancer risk among African American women by analyzing genetic data. It aims to improve the accuracy of polygenic risk scores (PRS) specifically for this population, which have previously been less effective compared to those developed for women of European ancestry. The study will utilize a large dataset that includes genetic information from thousands of African American women diagnosed with breast cancer, as well as data from other ancestries, to identify genetic variants associated with breast cancer risk. By refining these risk scores, the research seeks to provide better risk assessments for African American women, ultimately aiding in early detection and prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American women, particularly those with a family history of breast cancer or other risk factors.
Not a fit: Patients who are not of African descent or those who do not have a genetic predisposition to breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate breast cancer risk assessments for African American women, improving early detection and treatment options.
How similar studies have performed: Previous research has shown success in developing polygenic risk scores for other populations, but this approach for African American women is relatively novel and aims to address existing gaps.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Huo, Dezheng — University of Chicago
- Study coordinator: Huo, Dezheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.