Predicting Blood Clots in Ovarian Cancer Patients
Novel Biomarkers Predicting Blood Clots in Ovarian Cancer
This project looks for new ways to tell which ovarian cancer patients on chemotherapy might get dangerous blood clots.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11142554 on NIH RePORTER |
What this research studies
Ovarian cancer patients often face a serious risk of blood clots, especially during chemotherapy. While blood thinners can prevent these clots, they also increase the risk of bleeding for everyone. This project aims to find specific markers in tumor and blood samples that can predict which patients are most likely to develop clots. By identifying these markers, doctors hope to give blood thinners only to those who truly need them, avoiding unnecessary risks for others. Researchers are particularly interested in how cancer cells release certain components, like mitochondria, that might contribute to clot formation.
Who could benefit from this research
Good fit: Patients with ovarian cancer receiving chemotherapy who are at risk for blood clots are the focus of this research.
Not a fit: Patients without ovarian cancer or those not undergoing chemotherapy would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help doctors personalize blood clot prevention for ovarian cancer patients, reducing serious complications while avoiding unnecessary bleeding risks.
How similar studies have performed: Most previous studies have focused on general risk factors for blood clots, making this approach of investigating tumor-specific factors relatively novel.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Afshar-Kharghan, Vahid — University of Tx Md Anderson Can Ctr
- Study coordinator: Afshar-Kharghan, Vahid
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.