Predicting arm and hand recovery after stroke
Validation of Early Prognostic Data for Recovery Outcomes after Stroke for Future, Higher Yield Trials (VERIFY)
This project tests whether MRI and a quick, noninvasive brain-response test can predict arm and hand recovery for people who recently had an ischemic stroke.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11307002 on NIH RePORTER |
What this research studies
If you join, researchers will collect standard clinical exams, a brain MRI, and a brief transcranial magnetic stimulation (TMS) test early after your stroke. They will follow your arm and hand recovery for 90 days to see how well these measures match real outcomes. The team will use an existing prediction tool (PREP-2) plus the MRI and TMS results to group patients by likely recovery. This is a large, multi-site effort to validate these biomarkers so future trials and rehabilitation plans can be better targeted.
Who could benefit from this research
Good fit: Adults who recently had an ischemic stroke with motor (arm/hand) weakness and who can undergo MRI and noninvasive TMS in the early post-stroke period are the ideal candidates.
Not a fit: People with hemorrhagic stroke, unstable medical conditions, implanted devices that prevent MRI/TMS, or those outside the early post-stroke window may not be eligible or benefit from this study.
Why it matters
Potential benefit: If successful, clinicians could give more accurate recovery predictions and tailor rehabilitation plans earlier after stroke.
How similar studies have performed: Prior work shows that motor-evoked potentials and MRI measures of corticospinal injury relate to recovery and the PREP-2 tool has shown promise, but large multi-site validation is still needed.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Khatri, Pooja — Yale University
- Study coordinator: Khatri, Pooja
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.