Predicting and preventing type 2 diabetes in children and teens
The PRIORITY Study: from PRedIctiOn to pReventIon of youth-onset TYpe 2 diabetes
This project aims to find early warning signs and ways to prevent type 2 diabetes in children and adolescents, especially those with obesity or other risk factors.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11285442 on NIH RePORTER |
What this research studies
You would be followed from before or during puberty with regular clinic visits that include blood tests, glucose measures, and body measurements. The team will collect biological samples and information about diet, activity, mental health, and social environment to see how these factors relate to changing insulin sensitivity and beta-cell function. They will compare patterns in boys and girls and across different communities to find who is most likely to move from normal blood sugar to prediabetes or diabetes. This long-term follow-up aims to map the timeline of risk and spot targets that could be changed to prevent diabetes.
Who could benefit from this research
Good fit: Ideal candidates are children and adolescents—often with overweight or obesity or a family history of type 2 diabetes—who can be followed through puberty with periodic visits and tests.
Not a fit: People with long-standing, established type 2 diabetes or those unable to attend repeated visits are unlikely to get direct benefit from this prevention-focused project.
Why it matters
Potential benefit: If successful, the work could help identify kids at highest risk earlier and point to prevention steps that stop type 2 diabetes before it starts.
How similar studies have performed: Previous studies have described risk factors in youth but few have followed children through puberty to successfully prevent type 2 diabetes, so this longitudinal approach is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Magge, Sheela Natesh — Johns Hopkins University
- Study coordinator: Magge, Sheela Natesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.