Predicting Alzheimer’s risk in South Asian adults using genes, lifestyle, and heart health
P-CARRS-BRAIN: Multi-domain (genetic, socio-behavioral, vascular) risk factors and prediction of Alzheimer’s Disease continuum in South Asians in India
This project combines genetic, lifestyle, and cardiovascular information to help predict Alzheimer’s risk in middle-aged South Asian adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11393567 on NIH RePORTER |
What this research studies
This project builds on a long-running Precision-CARRS cohort of South Asian adults by adding dementia-focused cognitive testing and genetic analysis. Researchers will link socio-behavioral, environmental, and vascular/metabolic data collected over many years to define early changes across the Alzheimer’s disease continuum. They will use machine-learning models to combine high-dimensional data and try to identify who is most likely to progress toward symptomatic dementia. If you share health information or genetic samples, your data could help create better early-risk tools tailored to South Asian people.
Who could benefit from this research
Good fit: Adults of South Asian descent—especially middle-aged people with vascular or metabolic risk factors or those already enrolled in the Precision-CARRS cohort—are the ideal candidates.
Not a fit: People who are not of South Asian ancestry or those already living with advanced Alzheimer’s dementia are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, the work could identify people at higher risk earlier so they can get targeted prevention, monitoring, or entry into future trials.
How similar studies have performed: Related studies using genetic, vascular, and behavioral data have shown promise for predicting Alzheimer’s in other populations, but applying multimodal machine learning to South Asian cohorts is relatively new.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Narayan, Kabayam M Venkat — Emory University
- Study coordinator: Narayan, Kabayam M Venkat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.