Predicting Alzheimer’s risk in middle-aged South Asians using genes, lifestyle, and vascular health
P-CARRS-BRAIN: Multi-domain (genetic, socio-behavioral, vascular) risk factors and prediction of Alzheimer’s Disease continuum in South Asians in India
This project combines genetic, health, and lifestyle information to predict who among South Asian adults may develop Alzheimer’s changes later in life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11181490 on NIH RePORTER |
What this research studies
You would join a large, long-running South Asian health cohort where researchers will add memory-related testing and DNA sampling. They will link those new measures to years of medical, lifestyle, and vascular data already collected for each person. The team will use machine-learning methods to look for patterns that signal early Alzheimer’s changes and to find risk factors that can be changed. The work focuses on middle-aged adults to catch warning signs before dementia develops.
Who could benefit from this research
Good fit: Ideal candidates are South Asian adults (age 21 and older), especially middle-aged people with vascular or metabolic risk factors or a family history of dementia.
Not a fit: People who are not of South Asian descent, are far outside the target age range, or already have advanced Alzheimer’s dementia are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could identify people at higher Alzheimer’s risk earlier so they can get monitoring or preventive care sooner.
How similar studies have performed: Similar multimodal prediction approaches have shown promise in other populations, but this long-term, South Asian-focused effort is relatively new and less tested.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Narayan, Kabayam M Venkat — Emory University
- Study coordinator: Narayan, Kabayam M Venkat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.