Predicting Alzheimer's risk in middle-aged South Asians using genes, health, and lifestyle
P-CARRS-BRAIN: Multi-domain (genetic, socio-behavioral, vascular) risk factors and prediction of Alzheimer’s Disease continuum in South Asians in India
This project combines genetic data, health measures, and lifestyle information to find who among middle-aged South Asians in India may be on a path toward Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11393566 on NIH RePORTER |
What this research studies
You would be part of a large Precision-CARRS cohort that already has many years of health, lifestyle, and vascular data. The team will add Alzheimer’s-related cognitive testing and genetic testing and link those measures to the existing records. They will use machine learning across genetic, socio-behavioral, and vascular data to identify patterns that signal early Alzheimer’s changes. The goal is to create and validate models that predict who is likely to move along the Alzheimer’s disease continuum years before dementia appears.
Who could benefit from this research
Good fit: Adults of South Asian descent living in India—particularly middle-aged adults with vascular or metabolic risk factors and those enrolled or eligible for the Precision-CARRS cohort—are the intended participants.
Not a fit: People who are not of South Asian ancestry or those with advanced, symptomatic Alzheimer’s dementia are unlikely to benefit directly from the study’s early-detection focus.
Why it matters
Potential benefit: If successful, this work could help spot people at higher risk earlier so they can get preventive care or join prevention trials.
How similar studies have performed: Multimodal prediction and genetic-risk approaches have shown promise in other populations but are not well validated in South Asian groups, so this work is relatively novel for that population.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Narayan, Kabayam M Venkat — Emory University
- Study coordinator: Narayan, Kabayam M Venkat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.