Precision care for Latino gastric cancer using patient-derived tumor models
Advancing gastric cancer precision medicine in Latinos through patient-derived modeling
Building lab models from tumors of Latino patients to discover targeted treatment options for gastric cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11377101 on NIH RePORTER |
What this research studies
This project will build lab models from tumors donated by Latino people with gastric cancer so researchers can study the tumors' genetics. Researchers will focus on tumors that have overlapping changes in PI3K and CDK pathways and will grow patient-derived xenografts and other models from those samples. The team will test targeted drugs and drug combinations on these models to find treatments that may work better for tumor types common in Latino patients. The program partners with hospitals in California and Texas and aims to expand findings to other co-mutated tumor types.
Who could benefit from this research
Good fit: Latino individuals diagnosed with gastric cancer who can provide tumor tissue (from surgery or biopsy) and receive care at partnering centers are the ideal candidates.
Not a fit: People without gastric cancer, those unable to donate tumor tissue, or whose tumors do not have the specific co-mutations studied are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: Could lead to new targeted drug options and clinical trials better matched to gastric tumors common in Latino patients.
How similar studies have performed: Patient-derived tumor models and precision drug testing have produced promising leads in other cancers, but applying them specifically to Latino gastric cancer genetics is relatively novel.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Carvajal Carmona, Luis Guillermo — University of California at Davis
- Study coordinator: Carvajal Carmona, Luis Guillermo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.