Post-transcriptional regulation by YBX3 in skeletal muscle
Official title: Post-transcriptional regulation by the YBX3 RNA-binding protein in skeletal muscle
Funded at Haverford College · NIH-11291486 · Data updated 2026-11-12
A study is examining how the YBX3 RNA-binding protein controls gene messages in adult muscle to understand how muscles grow and regenerate.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Haverford College NIH-funded |
| Lab location | 1 site (Haverford, United States) |
| Project start | April 1, 2022 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $528,997 |
| NIH project number | 9R15AR087124-02 |
| Project ID | NIH-11291486 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with or at risk for muscle-related conditions where YBX3 pathways may be relevant.
✕Less likely to help
Patients without muscle growth or regeneration concerns may not directly benefit.
What this research studies
This project will map which messenger RNAs YBX3 binds and how this affects nutrient transport and muscle cell growth. It uses biochemistry, transcriptomics, bioinformatics, and cell culture to study YBX3’s role during muscle development and proliferation. The goal is to uncover how YBX3’s post-transcriptional control supports skeletal muscle formation and function, which could illuminate muscle-related diseases.
Why it matters
Potential benefit: If successful, the findings could shed light on mechanisms that support healthy muscle growth and regeneration, potentially informing therapies for muscle weakness.
How similar studies have gone: Previous work suggests RNA-binding proteins influence muscle biology, but this specific YBX3-focused pathway is novel.
Where this research is happening
-
Haverford College
Haverford, United States Active
Researchers
- Principal investigator: Cooke, Amy M. — Haverford College
- Study coordinator: Cooke, Amy M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.