Porous materials for safe storage and delivery of fluorinated chemicals and therapeutic gases
Renewal of "Taming Fluorine: Metal-Organic Frameworks for the Heterogeneous Delivery of Fluorinated Building Blocks"
This project develops porous materials that make it safer to handle and release hard-to-use fluorinated chemicals and therapeutic gases to help make better medicines and reduce tissue damage after events like heart attacks.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11090733 on NIH RePORTER |
What this research studies
Researchers are using porous materials called metal-organic frameworks (MOFs) and porous organic polymers (POPs) to trap gases and volatile chemicals as solid, easy-to-handle forms. That approach helps chemists install fluorinated and chlorinated pieces into complex drug molecules and lets clinicians explore controlled release of gasotransmitters such as hydrogen sulfide or carbon monoxide. The team has already shown in lab studies that MOFs can store fluorinated gases and can deliver hydrogen sulfide to reduce ischemia-reperfusion damage, and this renewal will expand those chemistry and delivery experiments. Most work is currently lab-based at Cornell with the long-term goal of translating successful methods toward clinical use.
Who could benefit from this research
Good fit: Patients who have experienced ischemia-reperfusion injury (for example after a heart attack) or who might be eligible for future clinical trials of gas-delivery therapies would be the main candidates for eventual clinical testing.
Not a fit: People with health problems unrelated to ischemia-reperfusion or who are seeking immediate clinical treatments are unlikely to benefit directly from this early-stage materials and chemistry research.
Why it matters
Potential benefit: If successful, this work could speed creation of new fluorinated drugs and enable safer, targeted delivery of therapeutic gases to limit tissue damage after heart attacks or similar injuries.
How similar studies have performed: Early preclinical work from this team and others has shown promising results, including published demonstrations that MOFs can store fluorinated gases and deliver hydrogen sulfide in lab models, but human testing has not yet been reported.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Milner, Phillip John — Cornell University
- Study coordinator: Milner, Phillip John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.