Pomegranate extract may help reduce inflammation in bowel diseases.
Pomegranate Extract and Its Microbial Metabolite Urolithin A Suppress IBD through Modulation of the Gut Microbiome and T Cell Inflammatory Immune Responses
This study is looking at whether pomegranate extract and a compound called urolithin A can help people with inflammatory bowel disease (IBD) by changing their gut bacteria and immune responses, with the hope of easing symptoms for those with conditions like Crohn's disease and ulcerative colitis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Greater Los Angeles Healthcare System NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11098425 on NIH RePORTER |
What this research studies
This research investigates how pomegranate extract and its metabolite, urolithin A, can influence inflammatory bowel disease (IBD) by modifying the gut microbiome and immune responses. The study focuses on dietary supplementation with these compounds to see if they can alleviate symptoms of IBD, such as those seen in Crohn's disease and ulcerative colitis. By examining how these substances affect gut bacteria and inflammatory pathways, the research aims to provide insights into new dietary interventions for managing IBD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
Not a fit: Patients without inflammatory bowel disease or those who do not respond to dietary interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary treatments that help manage and reduce the symptoms of inflammatory bowel disease.
How similar studies have performed: Previous research has shown promising results with dietary interventions in managing IBD, suggesting that this approach may be effective.
Where this research is happening
Los Angeles, United States
- VA Greater Los Angeles Healthcare System — Los Angeles, United States (Active)
Researchers
- Principal investigator: Li, Zhaoping — VA Greater Los Angeles Healthcare System
- Study coordinator: Li, Zhaoping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.