Polyamine metabolism changes in artery disease
Dysregulations in Polyamine Metabolism During Atherosclerosis
This project looks at how shifts in small molecules called polyamines affect blood vessel cells and plaque stability in people with atherosclerotic cardiovascular disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project ID | NIH-11286628 on NIH RePORTER |
What this research studies
From a patient perspective, researchers are examining how the pathway that makes polyamines becomes abnormal as artery plaque grows. They will study vascular smooth muscle cells and plaques using lab models, genetic and chromatin-accessibility tools (like ATAC-seq), and animal experiments to see how altering the enzyme ODC1 changes cell behavior. The team will link those molecular changes to extracellular matrix breakdown and calcification that make plaques unstable. Findings are meant to point toward targets that could stabilize plaques without broadly suppressing the immune system.
Who could benefit from this research
Good fit: Ideal participants would be adults with atherosclerotic cardiovascular disease (for example coronary artery disease, prior heart attack or stroke, carotid or peripheral artery disease) who can provide clinical data or biospecimens at the study site.
Not a fit: People without atherosclerotic disease or those seeking immediate clinical treatment rather than research participation are unlikely to get direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could point to new treatments that prevent plaque breakdown and vascular calcification, lowering the risk of heart attack and stroke without major immune suppression.
How similar studies have performed: Prior laboratory studies have linked polyamine biosynthesis and ODC1 to blood vessel cell behavior, but translating those findings into therapies for plaque stabilization is still novel.
Where this research is happening
Shreveport, United States
- Louisiana State Univ Hsc Shreveport — Shreveport, United States (Active)
Researchers
- Principal investigator: Yurdagul, Arif — Louisiana State Univ Hsc Shreveport
- Study coordinator: Yurdagul, Arif
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.