Point-of-care oxalate test to help kidney stone patients manage recurrence
Official title: A Point of Care Device for Patients with Oxalurias, the Oxalate Now
Funded at Analytical Diagnostic Solutions, INC. · NIH-11310574 · Data updated 2026-11-12
A new at-home or clinic point-of-care device helps people with calcium oxalate kidney stones monitor urinary oxalate and related markers to reduce recurrence.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Analytical Diagnostic Solutions, INC. NIH-funded |
| Lab location | 1 site (Mount Laurel, United States) |
| Project start | August 15, 2026 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $311,172 |
| NIH project number | 1R43DK146426-01 |
| Project ID | NIH-11310574 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with calcium oxalate kidney stones or a history of nephrolithiasis who would benefit from closer urinary marker monitoring.
✕Less likely to help
Patients without a history of calcium oxalate stones or those not using urinary marker-guided therapy may not benefit.
What this research studies
This grant supports developing and validating a quick, user-friendly device that can measure key urinary markers linked to calcium oxalate stones at the point of care. It aims to enable timely adjustments in treatment, such as citrate therapy or diuretics, based on real-time results. By linking measurements like oxalate and creatinine to an Ox/Crea ratio, the device could help patients and clinicians tailor therapy to prevent painful stone episodes. The work involves collaboration with an analytics-focused company to ensure accuracy, ease of use, and clear guidance for patients. The ultimate goal is to lower recurrence rates and reduce emergency visits through better, more accessible monitoring.
Why it matters
Potential benefit: If successful, patients could prevent stone episodes and improve quality of life through easier, on-site monitoring of stone risk.
How similar studies have gone: Previous approaches show that home-based monitoring can improve management, but this specific point-of-care device for oxalate and related markers is a novel effort with potential for greater impact.
Where this research is happening
-
Analytical Diagnostic Solutions, INC.
Mount Laurel, United States Active
Researchers
- Principal investigator: Harper, Robert — Analytical Diagnostic Solutions, INC.
- Study coordinator: Harper, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.