Platinum-based treatments and protective combinations for cyanide poisoning
Platinum Based Countermeasures and Combinations with Protective Agents
Developing fast-acting platinum-based medicines and partner agents to help people exposed to toxic cyanide.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11172552 on NIH RePORTER |
What this research studies
Researchers are using three different animal models to find platinum-based drugs that can quickly neutralize cyanide. They will optimize compounds for safety, absorption, and practical emergency use, and test combinations with protective metabolites like glyoxylate. A multidisciplinary team of chemists, pharmacologists, and toxicologists will down-select the best candidates and move the most promising approaches toward emergency-ready antidotes.
Who could benefit from this research
Good fit: People who suffer acute cyanide poisoning—such as from smoke inhalation, industrial accidents, or chemical exposure—would be the eventual candidates for these antidotes.
Not a fit: People with chronic low-level cyanide exposure, unrelated medical conditions, or poisonings from other substances are unlikely to benefit from these specific countermeasures.
Why it matters
Potential benefit: Could lead to fast, portable antidotes that save lives and reduce long-term harm after severe cyanide exposure.
How similar studies have performed: Existing antidotes work in some emergencies, but platinum-based scavengers are a newer approach with limited human testing so far.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Davisson, Vincent Jo — Purdue University
- Study coordinator: Davisson, Vincent Jo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.