Personalizing emergency and acute treatments
Official title: Personalizing EmerGency/Acute therapeuticS Utilizing Systems biology (PEGASUS-2)
Funded at Denver Health and Hospital Authority · NIH-11238019 · Data updated 2026-11-12
This program uses patients' medical records and biological samples to tailor medicines for people treated in emergency departments for common acute problems like pain, nausea, and heart issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Denver Health and Hospital Authority NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | February 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $408,900 |
| NIH project number | 5R35GM152157-04 |
| Project ID | NIH-11238019 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people who come to a participating emergency department with common acute issues such as severe pain, nausea, or cardiovascular symptoms and who agree to provide biospecimens and share their electronic health records.
✕Less likely to help
People with chronic stable conditions who are not treated in an emergency setting, or those unwilling to provide samples or allow access to medical records, are unlikely to benefit directly.
What this research studies
As a patient, your emergency department record would be linked to blood and other samples stored in the emergency medicine specimen bank for analysis of genes, proteins, metabolites, and epigenetic markers. Researchers will apply machine learning, polygenic risk scores, and multi-omic models to look for biological patterns that predict who will benefit from specific emergency medicines and who might get side effects. The team is expanding on prior PEGASUS work to include more drug types and to test their findings at additional hospitals to make sure results hold true for different groups. The goal is to turn these findings into tools that help clinicians pick safer, more effective medicines in acute care.
Why it matters
Potential benefit: Could help clinicians choose medicines in the emergency department that work better and cause fewer side effects.
How similar studies have gone: Precision-medicine and multi-omic approaches have shown promising results in other clinical areas and the project builds on earlier PEGASUS work, but applying these methods broadly in emergency care is relatively new.
Where this research is happening
-
Denver Health and Hospital Authority
Denver, United States Active
Researchers
- Principal investigator: Monte, Andrew Albert — Denver Health and Hospital Authority
- Study coordinator: Monte, Andrew Albert
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The PEGASUS-2 program is working to make emergency treatments safer and more effective by studying how different patients respond to medications, so they can create personalized treatment plans that help everyone feel better faster.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.