Personalizing antibiotic treatment for pneumonia in patients on ventilators
Official title: Personalizing Antimicrobial Use in Ventilator-Associated Pneumonia
Funded at University of Michigan at Ann Arbor · NIH-11118911 · Data updated 2026-11-12
This study is looking to make the treatment of ventilator-associated pneumonia better by finding ways to personalize how long patients need antibiotics, so they get the right care without extra side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 18, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $194,400 |
| NIH project number | 5K23AI177689-02 |
| Project ID | NIH-11118911 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are hospitalized patients who are on mechanical ventilation and diagnosed with ventilator-associated pneumonia.
✕Less likely to help
Patients who are not on mechanical ventilation or do not have ventilator-associated pneumonia may not benefit from this research.
What this research studies
This research focuses on improving the treatment of ventilator-associated pneumonia (VAP), a serious infection that affects patients on mechanical ventilation. The current standard treatment involves administering antibiotics for a fixed duration, which may not be suitable for all patients. The project aims to identify specific biomarkers in the lungs that can help tailor antibiotic treatment durations to individual patient needs. By validating new analytical methods, the research seeks to enhance the effectiveness of antibiotic therapy and reduce unnecessary side effects.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective antibiotic treatments for patients with ventilator-associated pneumonia, potentially improving recovery rates and reducing complications.
How similar studies have gone: Previous research has shown promise in personalizing antibiotic treatments based on biomarkers, indicating that this approach could lead to significant advancements in patient care.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Albin, Owen — University of Michigan at Ann Arbor
- Study coordinator: Albin, Owen
Related research
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-
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This study is looking at a new kind of breathing tube that might help prevent pneumonia in seriously ill patients on ventilators, and it will compare this new tube to a regular one to see if it makes a difference in keeping patients healthier.
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Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
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Endothelial inflammation memory after sepsis and pneumonia
A scientist is studying how blood vessel cells “remember” sepsis and why survivors get worse when they catch pneumonia, with the goal of finding better ways to reduce organ damage.
-
Bacterial Biofilm Therapy with a Human Antibody to Help Antibiotics Work Better
A human antibody drug is being studied to disrupt bacterial biofilms and help standard antibiotics clear infections, especially around implants and catheters, in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.