Personalized versus standard treatment for Helicobacter pylori eradication in Veterans
Official title: Randomized clinical trial of personalized vs standard of care treatment for Helicobacter pylori eradication among Veterans: “VA Eradicate HP”
Funded at VA San Diego Healthcare System · NIH-11291255 · Data updated 2026-11-12
A randomized trial tests a personalized treatment plan versus standard care to eradicate Helicobacter pylori in Veterans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | April 1, 2026 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| NIH project number | 1I01RD001530-01A2 |
| Project ID | NIH-11291255 on NIH RePORTER |
Who could benefit from this research
✓Could help
Veterans diagnosed with Helicobacter pylori infection who are candidates for antibiotic-based eradication therapy at VA San Diego Health Care System or affiliated sites.
✕Less likely to help
Patients with contraindications to standard eradication regimens or who are not eligible for personalized therapy may not benefit.
What this research studies
This trial aims to improve HP eradication by tailoring therapy to individual factors such as antibiotic resistance and host metabolism. Veterans diagnosed with HP infection would be randomized to receive either a personalized antibiotic regimen or the current standard therapy for 14 days, along with gastric acid suppression. The study will monitor eradication success, adverse effects, adherence, and factors like antibiotic resistance to understand what works best for this population. Results could guide more effective, targeted treatment strategies for HP among Veterans and reduce related cancer risk.
Why it matters
Potential benefit: If successful, this approach could increase HP cure rates and reduce complications and costs for Veterans.
How similar studies have gone: Prior studies suggest that tailoring antibiotics to resistance patterns can improve eradication, but results in Veterans populations are not yet established.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Shah, Shailja C — VA San Diego Healthcare System
- Study coordinator: Shah, Shailja C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.