Personalized vaccine to boost tumor-killing immune cells in ovarian cancer
Project 1
A personalized vaccine approach to boost tumor-killing CD8 T cells in people with ovarian cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project ID | NIH-11146383 on NIH RePORTER |
What this research studies
This project looks at the pieces of protein (antigens) shown on a patient’s ovarian tumor and on immune cells that present those antigens. Researchers will compare these antigen patterns and use computer tools plus lab testing to find patient-specific neoantigen peptides. They will load those peptides onto specially prepared dendritic cells made outside the body to train CD8 T cells to recognize and kill the tumor. The goal is to produce a broader and stronger T cell response that can better target each patient’s cancer.
Who could benefit from this research
Good fit: People with ovarian cancer who can provide tumor tissue and blood samples for neoantigen identification and immune testing would be the ideal candidates.
Not a fit: Patients whose tumors lack identifiable neoantigens or who cannot provide tumor or blood samples may not receive direct benefit from this work.
Why it matters
Potential benefit: Could lead to personalized dendritic cell-based vaccines that produce stronger tumor-killing T cells and improve outcomes for people with ovarian cancer.
How similar studies have performed: Personalized neoantigen vaccines have shown promising immune responses in other cancers, but this specific dendritic cell-loaded approach in ovarian cancer is relatively new.
Where this research is happening
Buffalo, United States
- Roswell Park Cancer Institute Corp — Buffalo, United States (Active)
Researchers
- Principal investigator: Kalinski, Pawel — Roswell Park Cancer Institute Corp
- Study coordinator: Kalinski, Pawel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.