Personalized Treatments for Liver Cancer
AN INTEGRATED PLATFORM FOR NOVEL PERSONALIZED LIVER CANCER THERAPEUTICS
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11131257
This research aims to discover new, personalized ways to treat liver cancer, especially for patients who haven't responded well to current options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11131257 on ClinicalTrials.gov |
What this research studies
Current treatments for advanced liver cancer often provide only modest improvements in survival and can cause significant side effects, without targeting specific tumor mutations. This project combines advanced chemical biology with specially engineered mouse models and 3D tumor organoids to find new drug targets. Researchers are working to understand how different genetic changes in tumors influence which treatments might work best. The ultimate goal is to develop personalized therapies that are more effective and have fewer side effects for people living with liver cancer.
Who could benefit from this research
Good fit: This research is focused on improving treatments for patients with hepatocellular carcinoma (HCC), the most frequent form of liver cancer.
Not a fit: Patients without liver cancer or those whose cancer does not involve the specific genetic drivers being studied may not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could lead to more effective and personalized treatments for liver cancer, potentially improving patient outcomes and quality of life.
How similar studies have performed: Current treatments for advanced liver cancer offer modest improvements, highlighting the critical need for novel and more effective approaches like those explored in this project.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUCCIONE, ERNESTO — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: GUCCIONE, ERNESTO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.