Personalized treatment matching for breast cancer using tumor genetics
Matching genotypes with personalized therapies: Development of a decision support infrastructure to augment the value of precision medicine
Researchers will create and try out a computer tool that matches tumor genetics with targeted treatments for people with breast cancer.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11145639 on NIH RePORTER |
What this research studies
You would have your tumor sequencing results processed by an automated decision-support system that links genetic findings to possible targeted therapies. The project combines genomic data with your clinical records to prioritize actionable mutations and reduce time-consuming manual searches. The team will pilot the tool at the Johns Hopkins Molecular Tumor Board, in partnering community medical centers, and within two ongoing clinical trials for women with breast cancer. If you receive care at a participating site, the system could help clinicians find targeted treatment options based on your tumor's genetics.
Who could benefit from this research
Good fit: Ideal candidates are people with breast cancer who have had or will have tumor genomic (next-generation sequencing) testing and who receive care at participating Johns Hopkins or partner sites or are enrolled in the linked clinical trials.
Not a fit: People without tumor genomic testing, with cancers other than breast cancer, or whose tumors lack actionable genetic changes may not directly benefit from this tool.
Why it matters
Potential benefit: If successful, this could help clinicians find effective targeted therapies faster and more accurately for patients with breast cancer.
How similar studies have performed: Other programs have helped clinicians interpret tumor genomics and suggest treatments, but fully automated, scalable systems integrated across clinical sites are still emerging.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Anagnostou, Valsamo — Johns Hopkins University
- Study coordinator: Anagnostou, Valsamo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.