Personalized surgery for treating sleep apnea in children with Down syndrome
Treatment of Obstructive Sleep Apnea with Personalized Surgery in Children with Down Syndrome (TOPS-DS)
['FUNDING_OTHER'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-10698151
This study is looking at a special kind of surgery to help kids with Down syndrome who have trouble breathing at night due to sleep apnea, using a method that helps doctors see exactly what’s causing the problem so they can tailor the treatment just for them.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-10698151 on ClinicalTrials.gov |
What this research studies
This research investigates a tailored surgical approach to treat obstructive sleep apnea (OSA) specifically in children with Down syndrome. It utilizes drug-induced sleep endoscopy (DISE) to observe and identify the specific anatomical obstructions causing OSA, allowing for personalized surgical interventions. The study aims to compare the effectiveness of this personalized approach against standard treatments, addressing the high prevalence of OSA in this population. By focusing on the unique anatomical challenges faced by children with Down syndrome, the research seeks to improve surgical outcomes and overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are children with Down syndrome who are diagnosed with obstructive sleep apnea.
Not a fit: Patients without Down syndrome or those who do not have obstructive sleep apnea may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective surgical treatments for obstructive sleep apnea in children with Down syndrome, improving their quality of life.
How similar studies have performed: Previous small case series have shown success with personalized DISE-directed surgery in treating OSA in children with Down syndrome, but this approach has not been extensively tested in larger randomized trials.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAM, DEREK J — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: LAM, DEREK J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.