Personalized support for people with opioid use disorder and chronic pain

Tailored Retention and Engagement for Effective integrated Treatment of OUD and Pain (TREETOP)

NIH-funded research University of Pittsburgh at Pittsburgh · NIH-11161498

This program offers tailored pain self-management plus extra engagement supports to help people with opioid use disorder and long-term pain stay in treatment and feel better.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Pittsburgh at Pittsburgh NIH-funded
Lab location1 site (Pittsburgh, United States)
Project IDNIH-11161498 on NIH RePORTER

What this research studies

You might be invited to join one of two randomized trials that adapt a pain self-management program specifically for people who have both chronic pain and opioid use disorder. The program pairs medication treatment (like buprenorphine when appropriate) with tailored coaching, outreach, and strategies to help you manage pain and remain in care. A stakeholder board made up of patients, community members, and policymakers helps shape how the program is delivered and how we keep people engaged. The work is happening across clinics in Appalachia (Pennsylvania and West Virginia), Oregon, and Baltimore and may include in-person and remote options.

Who could benefit from this research

Good fit: Adults who have opioid use disorder and co-occurring chronic pain, including people receiving or eligible for medications like buprenorphine at participating clinics.

Not a fit: People who do not have both OUD and chronic pain, or who are not willing to try self-management strategies or medication-based treatment, are unlikely to benefit from this program.

Why it matters

Potential benefit: If successful, this approach could improve pain control, increase staying in treatment, and reduce opioid-related harms for people with both conditions.

How similar studies have performed: Integrated medication and behavioral pain-management approaches have shown promise, but multi-site tailored retention strategies like these are relatively new.

Where this research is happening

Pittsburgh, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.