Personalized radiation treatment for HPV-related throat cancer
A personalized approach using hypoxia resolution to guide curative-intent radiation dose reduction to 30 Gy: A novel de-escalation paradigm for HPV-associated oropharynx cancers
This study is looking at a new way to give less radiation to patients with HPV-related throat cancer, using special scans to see how well they respond to treatment, so they can safely get a lower dose without losing effectiveness and hopefully experience fewer side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11167125 on NIH RePORTER |
What this research studies
This research investigates a personalized approach to reduce radiation doses for patients with HPV-associated oropharyngeal cancers. By using a specific imaging biomarker, the study aims to determine whether patients can safely receive a lower radiation dose of 30 Gy instead of the standard 70 Gy without compromising treatment effectiveness. The approach involves assessing patients' responses to initial chemotherapy and using PET scans to guide treatment decisions. This method seeks to minimize side effects while maintaining the efficacy of cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with early-stage or advanced-stage HPV-positive oropharyngeal cancers who are undergoing chemoradiation therapy.
Not a fit: Patients with non-HPV-related throat cancers or those who do not meet the specific criteria for treatment de-escalation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective radiation treatments for patients with HPV-related throat cancer.
How similar studies have performed: Previous studies have shown promising results with similar personalized treatment approaches, indicating potential for success in this novel application.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Lee, Nancy Y — Sloan-Kettering Inst Can Research
- Study coordinator: Lee, Nancy Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.