Personalized Mediterranean diet guided by your gut microbes for heart and metabolic health
The Gut Microbiome and Personalized Mediterranean Diet Interventions for Cardiometabolic Disease Prevention
Find out if using a person's gut microbes to tailor a Mediterranean-style diet can better prevent heart disease, diabetes, and related metabolic problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11118944 on NIH RePORTER |
What this research studies
You would be part of work that looks at stool and blood samples collected over time from people who followed Mediterranean-style diets in long-term trials. Scientists will use advanced methods to read microbial genes, which microbes are active, and circulating metabolites to see how each person's gut community changes diet effects. The team builds on earlier results suggesting that using a person's own gut microbes at the right time can help keep weight and metabolic improvements. Findings could inform personalized diet plans or microbiome-based approaches to keep heart and metabolic health on track.
Who could benefit from this research
Good fit: Adults at risk for cardiometabolic disease (for example, overweight, high blood pressure, high cholesterol, or prediabetes) who can provide stool samples and follow dietary guidance are the best fit.
Not a fit: People without cardiometabolic risk or those unwilling to provide stool samples or follow diet changes are unlikely to benefit from participation.
Why it matters
Potential benefit: Could lead to personalized diet advice or microbiome-based treatments that more reliably prevent heart disease, diabetes, and weight regain.
How similar studies have performed: Mediterranean diets have repeatedly shown cardiometabolic benefits and early trials suggest autologous fecal microbiota approaches can help maintain those benefits, but using combined metagenomics, metatranscriptomics, and metabolomics to personalize diet is a newer approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wang, Dong — Brigham and Women's Hospital
- Study coordinator: Wang, Dong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.