Personalized lifestyle changes for obesity treatment
Official title: Phenotype-Tailored Lifestyle intervention for Obesity: A Randomized Trial
Funded at Mayo Clinic Rochester · NIH-11134548 · Data updated 2026-11-12
This study is looking for ways to help people with obesity by creating personalized weight loss plans based on their unique traits, and it will compare these tailored plans to regular advice to see which works better for losing weight and keeping it off.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $668,784 |
| NIH project number | 5R01DK139028-02 |
| Project ID | NIH-11134548 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults aged 21 and older who are struggling with obesity and may have specific behavioral or physiological traits affecting their weight loss.
✕Less likely to help
Patients who are not classified as obese or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on developing a tailored approach to obesity treatment by identifying specific obesity phenotypes in patients. By understanding individual traits related to energy balance and behavior, the study aims to create personalized lifestyle interventions that enhance weight loss and help maintain it over time. Participants will be randomly assigned to receive either these tailored interventions or standard lifestyle recommendations, allowing researchers to compare the effectiveness of both approaches. The goal is to improve weight loss outcomes for individuals struggling with obesity.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized obesity treatments that significantly improve weight loss and maintenance for patients.
How similar studies have gone: Previous pilot studies have shown promising results with phenotype-tailored interventions, indicating potential for success in this larger randomized trial.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Acosta, Andres J — Mayo Clinic Rochester
- Study coordinator: Acosta, Andres J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.