Personalized heart risk prediction for childhood cancer survivors
Personalized Risk Prediction to Reduce Cardiovascular Disease in Childhood Cancer Survivors
This project helps predict and lower the chance of heart disease for people who survived cancer as children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11212382 on NIH RePORTER |
What this research studies
If I join, the team will use my past cancer treatment records—like heart radiation doses and chemotherapy—along with health data to estimate my personal risk of heart problems. They will build and test risk models that look at specific parts of the heart instead of treating the whole heart the same. The researchers will create tools clinicians can use to change radiation plans or to tailor follow-up heart screening and counseling for me and others. The work includes both looking back at existing survivor records and translating the models into tools for future care.
Who could benefit from this research
Good fit: Adults who survived cancer that began in childhood—especially those who had chest radiation or anthracycline chemotherapy and who can provide treatment records—are the best fit.
Not a fit: People without a history of childhood cancer, without treatment records, or whose heart problems are unrelated to past cancer therapy are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this could let doctors personalize radiation plans and follow-up so fewer survivors develop serious heart disease.
How similar studies have performed: Prior research linked heart radiation and anthracyclines to cardiovascular disease, but using detailed heart substructure dose models for personalized prediction is a newer approach with limited prior validation.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Howell, Rebecca Maureen — University of Tx Md Anderson Can Ctr
- Study coordinator: Howell, Rebecca Maureen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.