Personalized grafts for treating thoracic aortic aneurysms caused by genetics
Official title: Towards Personalized Prosthetic Graft Replacement for Genetically Triggered Thoracic Aortic Aneurysms
Funded at Weill Medical Coll of Cornell Univ · NIH-10878897 · Data updated 2026-11-12
This study is looking at how to make better, personalized grafts for people with thoracic aortic aneurysms to help reduce complications after surgery, especially for those who are genetically at risk, by using advanced imaging to understand their unique needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $691,821 |
| NIH project number | 5R01HL170570-02 |
| Project ID | NIH-10878897 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with genetically triggered thoracic aortic aneurysms who may require surgical intervention.
✕Less likely to help
Patients with thoracic aortic aneurysms not caused by genetic factors may not benefit from this research.
What this research studies
This research focuses on improving the treatment of thoracic aortic aneurysms (TAA) by developing personalized prosthetic grafts. It aims to address the increased risk of complications, particularly downstream dissections, that genetically predisposed patients face after standard graft replacement. The approach involves identifying specific markers of disease progression in the aorta after surgery, utilizing advanced imaging techniques like 4D flow MRI to monitor changes in aortic stiffness and blood flow dynamics. By tailoring grafts to individual patient needs, the goal is to enhance safety and outcomes for those affected by TAA.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of life-threatening complications for patients with genetically triggered thoracic aortic aneurysms.
How similar studies have gone: Previous research has shown promising results in using advanced imaging techniques to monitor aortic conditions, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Weinsaft, Jonathan W. — Weill Medical Coll of Cornell Univ
- Study coordinator: Weinsaft, Jonathan W.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.