Personalized gastric cancer care for Latinos using patient-derived tumor models
Advancing gastric cancer precision medicine in Latinos through patient-derived modeling
Using tumor samples from Latino patients to build models that help match gastric cancers to targeted medicines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11377136 on NIH RePORTER |
What this research studies
You would be asked to donate a small piece of your tumor at surgery or biopsy so researchers can grow it as a patient-derived model in the lab. The team will map genetic changes in those tumors—focusing first on PI3K and CDK pathway alterations common in Latino patients—and test targeted drugs on the models. The work is focused on Latino patients because they have higher rates of gastric cancer and distinct mutation patterns that may affect treatment response. Findings aim to guide future personalized treatment options and clinical trials for people like you.
Who could benefit from this research
Good fit: Latino adults with gastric cancer who can provide tumor tissue at surgery or biopsy—especially those whose tumors show PI3K and CDK pathway changes—are the best candidates to participate.
Not a fit: People without gastric cancer or whose tumors lack the targeted genetic changes are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this could help identify more effective, personalized treatment options for Latino patients with gastric cancer.
How similar studies have performed: Patient-derived tumor models and targeted drug testing have shown promise in preclinical and early clinical work, but applying this approach specifically to Latino gastric cancer and dual PI3K/CDK alterations is relatively new.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Carvajal Carmona, Luis Guillermo — University of California at Davis
- Study coordinator: Carvajal Carmona, Luis Guillermo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.