Personalized follow-up after polyp removal to prevent colorectal cancer
Personalizing Post-Polypectomy Surveillance for Colorectal Cancer Prevention
This project will build a practical tool using clinical history and genetic risk to guide how often people who've had precancerous colon polyps should get follow-up colonoscopies.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kaiser Foundation Research Institute NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project ID | NIH-11170494 on NIH RePORTER |
What this research studies
You would share your polyp history and health information and might provide a small blood or saliva sample for genetic testing. The team will combine clinical factors and a polygenic risk score to create a simple prediction tool for future advanced polyps or cancer. They will use existing patient records and new participants to test how well the tool performs compared with current guideline-based schedules. The aim is to reduce unnecessary colonoscopies for low-risk people and make sure higher-risk people get earlier surveillance.
Who could benefit from this research
Good fit: Adults who have had a precancerous colon polyp removed and are facing decisions about the timing of surveillance colonoscopy would be the ideal candidates.
Not a fit: People without a history of precancerous polyps or those already diagnosed with colorectal cancer are not the intended beneficiaries and likely would not be helped by this project.
Why it matters
Potential benefit: If successful, the tool could lower unnecessary colonoscopies and help catch high-risk cases earlier, reducing colorectal cancer risk and harms from unneeded procedures.
How similar studies have performed: Previous research has linked clinical factors and genetic risk scores to colorectal cancer risk, but combining these specifically to guide post-polypectomy surveillance is relatively new and not yet proven.
Where this research is happening
Oakland, UNITED STATES
- Kaiser Foundation Research Institute — Oakland, United States (Active)
Researchers
- Principal investigator: Lee, Jeffrey Kuang Zou — Kaiser Foundation Research Institute
- Study coordinator: Lee, Jeffrey Kuang Zou
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.