Personalized fluid management for patients with hospital-onset sepsis
Official title: Developing and Evaluating a Personalized Approach to Initial Fluid Resuscitation in Patients with Hospital-Onset Sepsis
Funded at University of Michigan at Ann Arbor · NIH-11031095 · Data updated 2026-11-12
This study is looking at the best ways to give fluids to hospitalized patients with sepsis to help them recover better, by tailoring the treatment to each person's needs and comparing it to the usual care they receive.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | February 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $174,960 |
| NIH project number | 1K23HL177175-01 |
| Project ID | NIH-11031095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who develop sepsis during their hospital stay.
✕Less likely to help
Patients who do not develop sepsis or those with community-onset sepsis may not benefit from this research.
What this research studies
This research investigates how to optimize fluid resuscitation for patients who develop sepsis while hospitalized. It aims to understand the effects of different fluid volumes on patient outcomes and to create a personalized approach based on individual physiological responses. By utilizing electronic health records, the study will analyze data to guide fluid administration more effectively. A pilot trial will then compare this personalized method to standard care during emergency evaluations.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and better outcomes for patients with hospital-onset sepsis.
How similar studies have gone: Previous research has shown promise in personalized approaches to fluid management, but this specific focus on hospital-onset sepsis is relatively novel.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Munroe, Elizabeth — University of Michigan at Ann Arbor
- Study coordinator: Munroe, Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.