Personalized epinephrine dosing for children in cardiac arrest
Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest (PEDICA)
['FUNDING_R01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10944195
This study is looking at how to give the right amount of epinephrine to kids who have a cardiac arrest in the hospital, so that their treatment can be more personalized and effective, helping them have a better chance of survival during CPR.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10944195 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the treatment of pediatric in-hospital cardiac arrest by developing personalized methods for administering epinephrine. It aims to move away from standard dosing practices and instead tailor the dosage based on individual patient characteristics and real-time physiological responses. By analyzing how different children respond to epinephrine, the research seeks to enhance the effectiveness of cardiopulmonary resuscitation (CPR) and increase the chances of survival. The study will involve collecting data on various patient responses to optimize dosing strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who experience in-hospital cardiac arrest.
Not a fit: Patients who are not hospitalized or those outside the pediatric age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and outcomes for children experiencing cardiac arrest in hospitals.
How similar studies have performed: Previous research has shown variability in responses to epinephrine in pediatric patients, indicating that personalized approaches may lead to better outcomes, though this specific methodology is novel.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MORGAN, RYAN WILLIAM — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: MORGAN, RYAN WILLIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.