Personalized epinephrine dosing for children in cardiac arrest
Official title: Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest (PEDICA)
Funded at Children's Hosp of Philadelphia · NIH-10944195 · Data updated 2026-11-12
This study is looking at how to give the right amount of epinephrine to kids who have a cardiac arrest in the hospital, so that their treatment can be more personalized and effective, helping them have a better chance of survival during CPR.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $822,181 |
| NIH project number | 1R01HL175433-01 |
| Project ID | NIH-10944195 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who experience in-hospital cardiac arrest.
✕Less likely to help
Patients who are not hospitalized or those outside the pediatric age range may not benefit from this research.
What this research studies
This research focuses on improving the treatment of pediatric in-hospital cardiac arrest by developing personalized methods for administering epinephrine. It aims to move away from standard dosing practices and instead tailor the dosage based on individual patient characteristics and real-time physiological responses. By analyzing how different children respond to epinephrine, the research seeks to enhance the effectiveness of cardiopulmonary resuscitation (CPR) and increase the chances of survival. The study will involve collecting data on various patient responses to optimize dosing strategies.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and outcomes for children experiencing cardiac arrest in hospitals.
How similar studies have gone: Previous research has shown variability in responses to epinephrine in pediatric patients, indicating that personalized approaches may lead to better outcomes, though this specific methodology is novel.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Morgan, Ryan William — Children's Hosp of Philadelphia
- Study coordinator: Morgan, Ryan William
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
-
Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
-
Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
-
Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
-
Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.