Personalized cystic fibrosis testing using patient-derived cell models
Personalized Cystic Fibrosis Therapy and Research Center
This center uses each person's cells to create models that help find the best treatments for people with cystic fibrosis.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11140827 on NIH RePORTER |
What this research studies
I would provide tissue so researchers can grow patient-specific intestinal cultures (enteroids) and stem-cell–derived tissues from my cells. Scientists use these models to study how the CFTR protein and fluid balance work in my own cells and to test drugs on those models. The core will develop, validate, and bank these models and assays and provide them and training to researchers locally and around the world. Over time the goal is to use results from my cells to guide personalized treatment choices.
Who could benefit from this research
Good fit: People with cystic fibrosis, including pediatric patients treated at Cincinnati Children's, who are willing to donate tissue samples for enteroid or iPSC creation are ideal candidates.
Not a fit: People without cystic fibrosis or those unable or unwilling to provide the necessary tissue samples would not directly benefit from this program.
Why it matters
Potential benefit: If successful, this could let clinicians choose cystic fibrosis treatments that are more likely to work for each patient based on tests run on their own cells.
How similar studies have performed: Related studies using intestinal organoids and iPSC-derived cells have shown promise in predicting response to CFTR-targeting therapies, but broader clinical implementation is still being developed.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Naren, Anjaparavanda P — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Naren, Anjaparavanda P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.