Personalized care for severe allergic (anaphylactic) reactions
Improving Anaphylaxis Outcomes Through Personalized Care Strategies
This project uses machine learning to tailor emergency care and observation times so many children with anaphylaxis can spend less time in the ED or safely recover at home.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11251329 on NIH RePORTER |
What this research studies
If your child has a severe allergic reaction (anaphylaxis), the team will collect clinical details and treatment timing in the emergency department and add them to a growing patient cohort. They will use machine learning on that real-world data to predict how quickly symptoms will resolve for each patient. The goal is to recommend shorter observation or safe home management for low-risk cases while flagging those who need longer ED monitoring or hospitalization. The work builds on early data showing many patients improve within two hours after epinephrine and will test these prediction tools prospectively at Cincinnati Children’s.
Who could benefit from this research
Good fit: Children who experience anaphylaxis and present to the emergency department—especially those treated with epinephrine—are the ideal candidates for enrollment.
Not a fit: Patients with atypical allergic presentations, complex medical conditions, delayed care, or who do not present to the participating ED are less likely to benefit from this project.
Why it matters
Potential benefit: If successful, this approach could shorten ED observation times, reduce unnecessary hospital admissions, and help more patients with anaphylaxis recover safely at home.
How similar studies have performed: Early cohort data show many patients resolve quickly after epinephrine, but using real-time machine learning to customize observation periods is a novel and not yet proven approach.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Dribin, Timothy Erick — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Dribin, Timothy Erick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.