Personalized blood‑flow modeling for newborns with a small left heart
Personalized Computational Modeling for Predicting Hemodynamics in Borderline Left Ventricles
This project uses individualized computer models of heart blood flow to help doctors choose the best surgical path for newborns with a borderline left ventricle.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11163478 on NIH RePORTER |
What this research studies
This work creates computer models from each baby's heart images to simulate blood flow and pressures. The team will use those simulations to compare outcomes of keeping two working ventricles versus using a single‑ventricle approach. The methods combine imaging, physics‑based modeling, and advanced statistical techniques to make predictions tailored to each infant. Results aim to give families clearer information when deciding timing and type of surgery.
Who could benefit from this research
Good fit: Newborns and young infants diagnosed with a borderline left ventricle who are being considered for biventricular repair or single‑ventricle palliation are the intended candidates.
Not a fit: Infants whose left heart is clearly normal or clearly too small for a two‑ventricle repair (classic hypoplastic left heart) or unrelated adult patients are unlikely to benefit from this work.
Why it matters
Potential benefit: If successful, the models could lower surgical risk and improve long‑term outcomes by guiding selection of the surgical approach that best fits each infant's heart.
How similar studies have performed: Personalized hemodynamic modeling has shown promise in small research series, but applying it specifically to guide the BiVR versus SVP decision is relatively new and still experimental.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Vedula, Vijay — Columbia Univ New York Morningside
- Study coordinator: Vedula, Vijay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.