Personalized blood‑flow modeling for newborns with a small left heart
Official title: Personalized Computational Modeling for Predicting Hemodynamics in Borderline Left Ventricles
Funded at Columbia Univ New York Morningside · NIH-11163478 · Data updated 2026-11-12
This project uses individualized computer models of heart blood flow to help doctors choose the best surgical path for newborns with a borderline left ventricle.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 7, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $180,882 |
| NIH project number | 5R21LM014481-02 |
| Project ID | NIH-11163478 on NIH RePORTER |
Who could benefit from this research
✓Could help
Newborns and young infants diagnosed with a borderline left ventricle who are being considered for biventricular repair or single‑ventricle palliation are the intended candidates.
✕Less likely to help
Infants whose left heart is clearly normal or clearly too small for a two‑ventricle repair (classic hypoplastic left heart) or unrelated adult patients are unlikely to benefit from this work.
What this research studies
This work creates computer models from each baby's heart images to simulate blood flow and pressures. The team will use those simulations to compare outcomes of keeping two working ventricles versus using a single‑ventricle approach. The methods combine imaging, physics‑based modeling, and advanced statistical techniques to make predictions tailored to each infant. Results aim to give families clearer information when deciding timing and type of surgery.
Why it matters
Potential benefit: If successful, the models could lower surgical risk and improve long‑term outcomes by guiding selection of the surgical approach that best fits each infant's heart.
How similar studies have gone: Personalized hemodynamic modeling has shown promise in small research series, but applying it specifically to guide the BiVR versus SVP decision is relatively new and still experimental.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Vedula, Vijay — Columbia Univ New York Morningside
- Study coordinator: Vedula, Vijay
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.