Personalized antibiotic treatment for urinary tract infections in the emergency department
Official title: Personalized Antibiotic Therapy in the Emergency Department: PANTHER Trial
Funded at University of Iowa · NIH-10839481 · Data updated 2026-11-12
This study is looking at a new way to treat urinary tract infections (UTIs) for people who have just left the emergency room, where you can decide how long to take antibiotics based on how you're feeling, instead of sticking to a set time, which might help you avoid taking unnecessary medicine and reduce side effects.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | May 9, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $172,687 |
| NIH project number | 5R21AI175751-02 |
| Project ID | NIH-10839481 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing urinary tract infections who are being treated in the emergency department.
✕Less likely to help
Patients with severe infections requiring hospitalization or those with complex medical conditions may not benefit from this research.
What this research studies
This research investigates a new approach to treating urinary tract infections (UTIs) in patients discharged from the emergency department. Instead of following the traditional method of prescribing a fixed duration of antibiotics, the study explores a patient-directed approach where treatment duration is based on the resolution of symptoms. This could help reduce unnecessary antibiotic use, lower the risk of adverse effects, and combat antibiotic resistance. The trial aims to evaluate the effectiveness and safety of this personalized treatment strategy compared to standard care.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer antibiotic treatment for patients with UTIs, reducing the risk of antibiotic resistance.
How similar studies have gone: While the concept of patient-directed antibiotic therapy is promising, this specific approach has not been extensively tested in clinical trials, making it a novel investigation.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Faine, Brett — University of Iowa
- Study coordinator: Faine, Brett
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.