Personalized antibiotic treatment for Gram-negative infections
Improving Empiric Antimicrobial Therapy for Gram-Negative Infections through a Personalized Smart Antibiogram
This study is looking to make antibiotic treatments work better for infections caused by tough-to-treat Gram-negative bacteria by creating a personalized tool that helps doctors choose the right antibiotics based on each patient's unique situation, helping to avoid unnecessary use of stronger antibiotics.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10933405 on NIH RePORTER |
What this research studies
This research aims to improve the effectiveness of antibiotic treatments for infections caused by Gram-negative bacteria, which are increasingly resistant to standard therapies. By developing a personalized smart antibiogram, the project will analyze how clinicians currently use antibiograms and how these tools can be enhanced to better reflect individual patient risks of antimicrobial resistance. The approach involves collecting and analyzing patient-level data to guide more precise antibiotic choices, ultimately aiming to reduce the misuse of broad-spectrum antibiotics.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with infections caused by Gram-negative bacteria who may benefit from personalized antibiotic therapy.
Not a fit: Patients with infections caused by non-Gram-negative bacteria or those who do not require antibiotic treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored antibiotic treatments, reducing the risk of treatment failure and improving patient outcomes.
How similar studies have performed: Other research has shown promise in using personalized approaches to antibiotic therapy, indicating that this method could lead to significant advancements in treatment.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Goto, Michihiko — University of Iowa
- Study coordinator: Goto, Michihiko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.