Personalized antibiotic dosing for critically ill patients
Beta-lactam individualization for critically ill patients
This study is working on a new way to give the right amount of antibiotics to seriously ill patients in the ICU, so they get the best treatment for their needs and avoid problems like treatment failures or antibiotic resistance.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10734057 on NIH RePORTER |
What this research studies
This research focuses on improving the use of beta-lactam antibiotics in critically ill patients by developing a personalized dosing and monitoring tool. The study aims to address the significant variability in drug levels that can lead to treatment failures and increased antibiotic resistance. By creating individualized dosing models and dynamic prediction tools, the research seeks to ensure that patients receive the most effective antibiotic therapy tailored to their specific needs. This approach will help identify patients at risk of inadequate treatment or adverse effects during their care in the intensive care unit.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill patients in the intensive care unit who require beta-lactam antibiotics.
Not a fit: Patients who are not critically ill or do not require antibiotic treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective antibiotic treatments, reducing the risk of treatment failure and antibiotic resistance in critically ill patients.
How similar studies have performed: Previous research has shown promise in individualized dosing approaches for antibiotics, indicating potential for success in this novel application.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Barreto, Erin Frazee — Mayo Clinic Rochester
- Study coordinator: Barreto, Erin Frazee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.