Personalized Antibiotic Combinations for Resistant Infections
Personalized Antimicrobial Combinations to Combat Resistance
This project aims to find the best combinations of antibiotics to fight serious infections that no longer respond to single medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11136370 on NIH RePORTER |
What this research studies
The grant addresses the growing problem of bacteria that resist many antibiotics, making infections very hard to treat. Currently, doctors often guess which antibiotic combinations might work. This project is developing a new system, including a device and a computer program, to help doctors choose the most effective antibiotic combinations for each patient's specific infection. By quickly testing how a patient's bacteria respond to different drug combinations, this system hopes to provide personalized treatment plans. This could help overcome antibiotic resistance and improve patient outcomes.
Who could benefit from this research
Good fit: Patients with serious infections caused by bacteria that are resistant to many common antibiotics, such as Pseudomonas aeruginosa or Acinetobacter baumannii, would be the primary beneficiaries of this research.
Not a fit: Patients with infections that are easily treated by existing single antibiotics or those without bacterial infections would not directly benefit from this specific approach.
Why it matters
Potential benefit: If successful, this work could lead to more effective, personalized treatments for severe antibiotic-resistant infections, helping patients recover when standard antibiotics fail.
How similar studies have performed: While combination therapy is used, a robust, data-driven method for rationally selecting personalized combinations, as proposed here, represents a novel and less tested approach.
Where this research is happening
Houston, United States
- University of Houston — Houston, United States (Active)
Researchers
- Principal investigator: Tam, Vincent H — University of Houston
- Study coordinator: Tam, Vincent H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.