Personalized anesthesia care for Asian American patients
Precision medicine for Asian Americans requiring anesthesia
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-11376319
This project tests whether genetic variants common in people of East Asian descent make it harder to clear toxic chemicals produced during surgery, with the goal of making anesthesia safer for Asian American patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11376319 on ClinicalTrials.gov |
What this research studies
Researchers will study genetic differences common in people of East Asian ancestry that affect how the body handles reactive aldehydes produced during surgery. They built a mouse model carrying the human genetic variant that reduces aldehyde breakdown and developed sensitive lab tests to measure these toxic aldehydes. The team will look at how changes in the lipid peroxidation pathway influence organ injury after anesthesia-related stress. Results are intended to point toward strategies that could be translated to patients to lower organ damage during and after surgery.
Who could benefit from this research
Good fit: Adults of East Asian ancestry who are planning surgery or are interested in genetic screening related to aldehyde metabolism would be the most relevant candidates.
Not a fit: People who do not carry the East Asian aldehyde-metabolism variant, who are not of East Asian ancestry, or who are not undergoing surgery are unlikely to gain direct benefit from this work.
Why it matters
Potential benefit: Could enable genetic-based anesthesia approaches that reduce organ injury and improve surgical safety for Asian American patients and potentially others.
How similar studies have performed: Prior animal and human studies link aldehyde metabolism to tissue injury, but applying this knowledge specifically to anesthesia-related organ damage is a newer area of work.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GROSS, ERIC RICHARD — STANFORD UNIVERSITY
- Study coordinator: GROSS, ERIC RICHARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.