Personality and Dementia: How traits shape disease and progression
Official title: Personality and Dementia: Mechanisms and Trajectories
Funded at Florida State University · NIH-11447026 · Data updated 2026-11-12
This project looks at how personality traits might influence how people respond to Alzheimer’s pathology and how the disease progresses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | September 15, 2020 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $2,481,810 |
| NIH project number | 2RF1AG068093-06 |
| Project ID | NIH-11447026 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with or at risk for Alzheimer’s disease and related dementias who have age-related biomarker data or pathology.
✕Less likely to help
People without any risk factors or biomarker indicators related to AD pathology are less likely to benefit from this research.
What this research studies
Scientists at Florida State University are studying how psychological factors like personality traits affect dementia progression in people with Alzheimer’s pathology. The work builds on prior findings that traits such as neuroticism and conscientiousness relate to dementia risk and brain pathology, and it aims to uncover mechanisms and trajectories in a broad longitudinal context. The study will examine how these traits interact with biomarkers, using blood-based indicators to understand resilience vs. decline as people age. Results could inform personalized risk profiles and timing of interventions for those at risk or living with AD pathology.
Why it matters
Potential benefit: If successful, the work could lead to personalized approaches for monitoring and managing dementia risk based on personality and biomarker profiles.
How similar studies have gone: Previous studies have linked personality traits with dementia risk and pathology, and this renewal aims to extend those findings to mechanisms and trajectories.
Where this research is happening
-
Florida State University
Tallahassee, United States Active
Researchers
- Principal investigator: Terracciano, Antonio — Florida State University
- Study coordinator: Terracciano, Antonio
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.