Perioperative pain self-management to prevent long-term pain and opioid use

Preventing Chronic Post-Surgical Pain and Prolonged Opioid Use: The Perioperative Pain Self-Management Program

NIH-funded research Iowa City VA Medical Center · NIH-11370957

This project tests whether a short cognitive-behavioral perioperative pain self-management program helps surgical patients avoid chronic post-surgical pain and prolonged opioid use.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionIowa City VA Medical Center NIH-funded
Lab location1 site (Iowa City, United States)
Project IDNIH-11370957 on NIH RePORTER

What this research studies

If you are having surgery, researchers offer a brief perioperative program called PePS that teaches pain self-management and CBT-based coping skills before and after surgery. In a randomized trial, some patients receive PePS plus usual care while others receive standard care, and outcomes like chronic pain and length of opioid use after surgery are tracked. The study focuses on Veterans and will examine whether people with substance use disorders respond differently. The aim is to prevent the development of long-term pain and prolonged opioid use rather than treating established chronic pain.

Who could benefit from this research

Good fit: Ideal candidates are adults scheduled for surgery—particularly Veterans—who are worried about post-surgical pain or opioid use and who can participate in brief perioperative behavioral sessions.

Not a fit: Patients with long-standing chronic pain unrelated to the upcoming surgery or those unable to take part in brief behavioral sessions may be unlikely to benefit.

Why it matters

Potential benefit: If successful, this program could reduce the chance of chronic post-surgical pain and lower rates of prolonged opioid use after surgery.

How similar studies have performed: CBT and psychological interventions have helped people with chronic pain, but using a CBT-style program specifically to prevent chronic post-surgical pain is a newer, less-tested approach.

Where this research is happening

Iowa City, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.