Pellino1's role in helping skin fight herpes infections
Pellino1 as a regulator of antiviral immunity in the epidermis
Researchers are looking at whether a skin protein called Pellino1 helps adults' skin stop herpes virus reactivation, especially in people with atopic dermatitis or weakened skin barriers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11232309 on NIH RePORTER |
What this research studies
From a patient's perspective: the team uses lab models and specially bred mice to see how Pellino1 affects herpes simplex virus behavior in the skin and hair follicles. They study immune signals (like IL-1 and IL-36) and how loss of Pellino1 changes virus spread and lesion severity. The work combines mouse infection models with cell experiments to pin down how Pellino1 controls antiviral responses. Findings are intended to point toward new ways to boost skin immunity or identify people at higher risk of severe outbreaks.
Who could benefit from this research
Good fit: Adults who experience recurrent herpes simplex outbreaks or people with atopic dermatitis and frequent skin infections would be the most relevant candidates for follow-up trials or sample donation.
Not a fit: People without skin-related herpes infections, children, or those whose conditions are unrelated to skin antiviral immunity are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could point to new treatments or strategies to strengthen skin antiviral defenses and reduce painful HSV outbreaks for vulnerable patients.
How similar studies have performed: Prior animal studies of Pellino1 gave mixed results for RNA viruses, but early mouse work here shows Pellino1 loss worsens HSV outcomes, so translation to humans remains unproven.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Jensen, Liselotte E — Temple Univ of the Commonwealth
- Study coordinator: Jensen, Liselotte E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.